new paradigms for the biological sciences
focus of Joshua Tietjen's GSTP supported graduate
research will be on determining what the regulatory
circuitry of E. coli consists of under
various growth conditions and examining the
changes that occur as the input parameters are
altered. This research could serve as a platform
for the elucidation of regulatory networks on
a genome-wide scale and allow for the develpment
of robust in silico tools. Two questions will
be addressed: 1) What genes are transcribed
by which class of holoenzymens in the E.
coli genome under specific growth conditions,
and 2) What mathematical models can be develpoed
for predicting the transcirptional state of
the organism for a given input condition?