Microbiology Graduate Program
Faculty Advisor: Aseem Ansari
The focus of Joshua Tietjen’s GSTP supported graduate research will be on determining what the regulatory circuitry of E. coli consists of under various growth conditions and examining the changes that occur as the input parameters are altered. This research could serve as a platform for the elucidation of regulatory networks on a genome-wide scale and allow for the develpment of robust in silico tools. Two questions will be addressed: 1) What genes are transcribed by which class of holoenzymens in the E. coli genome under specific growth conditions, and 2) What mathematical models can be develpoed for predicting the transcirptional state of the organism for a given input condition?